This study presented new annual maps of irrigated cropland in China from 2000 to 2020 (CIrrMap250). These maps were developed by integrating remote sensing data, irrigation statistics and surveys, and an irrigation suitability map. CIrrMap250 achieved high accuracy and outperformed currently available products. The new irrigation maps revealed a clear expansion of China’s irrigation area, with the majority (61%) occurring in the water-unsustainable regions facing severe to extreme water stress.