We produced a monthly Universal Thermal Climate Index dataset (GloUTCI-M) boasting global coverage and an extensive time series spanning March 2000 to October 2022 with a high spatial resolution of 1 km. This dataset is the product of a comprehensive approach leveraging multiple data sources and advanced machine learning models. GloUTCI-M can enhance our capacity to evaluate thermal stress experienced by the human, offering substantial prospects across a wide array of applications.