We introduce HydroWASTE, a spatially explicit global database of 58 502 wastewater treatment plants (WWTPs) and their characteristics to understand the impact of discharges from such facilities. HydroWASTE was developed by compiling regional datasets and using auxiliary information to complete missing characteristics. The location of the outfall of the WWTPs into the river system is also included, allowing for the identification of the waterbodies most likely affected.