This work presents two data sets: a digital elevation model in which deforestation effects were minimized over a large area in Central Amazonia and a set of 18 topographic–hydrological descriptors calculated by the use of the Vertical Distance to the Nearest Drainage algorithm (HAND). We describe the methodology to generate and validate the data sets. Moreover, we present a brief discussion about the applicability of the data to fill the gap of environmental data in Amazonian lowland forests.